Chemical Biology

2 insights in this topic

How Photoredox Chemistry Turns Simple Amino Acids into Chiral Building Blocks?
Chemical Biology

How Photoredox Chemistry Turns Simple Amino Acids into Chiral Building Blocks?

This work demonstrates a powerful photoredox-enabled strategy for the asymmetric functionalization of amino acids via hydrogen atom transfer–driven radical chemistry. By combining broad substrate scope, high stereocontrol, and scalability, the study highlights the growing maturity of photoredox catalysis as a practical tool for complex molecule synthesis.

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How Light Rewires Amino Acids into Serotonin Receptor Ligands
Radical Photochemistry

How Light Rewires Amino Acids into Serotonin Receptor Ligands

This work shows that light-driven radical rearrangements can convert amino acids into structurally constrained tryptamine derivatives with direct relevance to serotonin receptor biology. By enabling selective C4 indole functionalization and rapid scaffold construction, the study highlights photochemistry as a powerful tool for generating medicinally relevant molecular complexity.

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